Detailed Notes on Conolidine alkaloid for chronic pain
Most a short while ago, it's been identified that conolidine and the above derivatives act on the atypical chemokine receptor 3 (ACKR3. Expressed in identical regions as classical opioid receptors, it binds to a wide array of endogenous opioids. Unlike most opioid receptors, this receptor acts to be a scavenger and won't activate a second messenger